Optimization of Dexamethasone Mixed Nanomicellar Formulation
نویسندگان
چکیده
منابع مشابه
Formulation Optimization and Assessment of Dexamethasone Orally Disintegrating Tablets Using Box-Behnken Design
The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...
متن کاملFormulation Optimization and Assessment of Dexamethasone Orally Disintegrating Tablets Using Box-Behnken Design
The aim of this study was to prepare orally disintegrating tablets (ODTs) containingdexamethasone (DEX) by direct compression method with sufficient hardness and rapiddisintegration time. In order to save time, money, and human resources in designing andimprovement of formulation, the statistical software Design Expert is used. Box–Behnkenresponse surface methodology was applied to evaluate and...
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BACKGROUND Although demonstrated as a selective anticancer drug, the clinical use of clotrimazole (CTZ) is limited due to its low solubility in hydrophilic fluids. Thus, we prepared a water-soluble nanomicellar formulation of CTZ (nCTZ) and tested on the human breast cancer cell line MCF-7 biology. METHODOLOGY/PRINCIPAL FINDINGS CTZ was nanoencapsulated in tween 80 micelles, which generated n...
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One of the common approaches for improving the reliability of a specific system is to use parallel redundant components in subsystems. This approach, which is known as the redundancy allocation problem (RAP), includes the simultaneous selection of the component type and its level for each subsystem in order to maximize the system reliability.Traditionally, there are two redundancy strategies, n...
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ژورنال
عنوان ژورنال: AAPS PharmSciTech
سال: 2014
ISSN: 1530-9932
DOI: 10.1208/s12249-014-0159-y